A review of the correlation between human papillomavirus (HPV) infection and dysbiosis of the female reproductive tract

Authors

  • Ying Wang PHILIPPINE CHRISTIAN UNIVERSITY Taft Avenue, Manila Philippines Author

DOI:

https://doi.org/10.63313/hmt.9007

Keywords:

This text discusses: vaginal microbiome, human papillomavirus (HPV), imbal-ance of the microbiome, and women's reproductive health issues.

Abstract

This article reviews the relationship between vaginal microecological imbalance and cervical HPV infection, highlighting the latest research advancements in this area. As the primary defense line of the female reproductive tract, the balance of vaginal microecology plays a crucial role in how susceptible someone is to HPV infections, how long those infections last, and how effectively they can be cleared. Recent studies have shown that the variety and stability of vaginal bacteria are closely linked to cervical HPV infections. Dysbiosis of the vaginal microecology may lead to changes in the local immune microenvironment, thereby weakening the host's resistance to HPV. Additionally, inflammatory re-sponses play an important role in the occurrence and progression of HPV infections. Through the analysis of existing research, this article further explores the potential application value of microecological regu-lation, including combating HPV infections by adjusting microbial struc-ture and restoring microecological balance. By integrating this research evidence, the article aims to provide theoretical support for clinical practice and future research directions to promote the development of early prevention and intervention strategies for HPV.

References

[1] Shanta, V., Krishnamurthi, S., Gajalakshmi, C. K., Swaminathan, R., & Ravichandran, K. (2000). Epidemiology of cancer of the cervix: global and national perspective. Journal of the Indian Medical Association, 98(2), 49–52.

[2] Lang Jinghe. (2024). Accelerating the achievement of the goal of "eliminating cervical cancer". New Scientific Life (09), 15.

[3] National Health Commission,Ministry of Education,Ministry of Civil Affairs,Ministry of Fi-nance,National Medical Insurance Bu-reau,National Bureau of Traditional Chinese Medi-cine... & All-China Women's Federation.(2023).Accelerating the Elimina-tion of Cervical Cancer Action Plan (2023-2030). Chinese Journal of Viral Diseases, 13(04), 243-244.

[4] Liu Yanbo, Jin Xin, Ling Xinru & Feng Guannan. (2025). Research progress on the correla-tion between vaginal microecological flora and cervical human papillomavirus infection. Anhui Medical Journal (05), 869-874.

[5] Li Mingzhu & Wei Lihui. (2025). Diversion and management of high-risk HPV persistent positive population. Chinese Journal of Obstetrics and Gynecology Clinical, 26(01), 1-2.

[6] Cui Qian & Xu Yinghui. (2024). Research progress on the appli-cation of probiotics in ob-stetric and gynecological diseases and their mechanisms of action. Chinese Journal of Mi-croecology, 36(12), 1474-1479+1484.

[7] Zhang Min, Li Xiaocong & Ding Haitao. (2024). Research Pro-gress on the Correlation be-tween Vaginal Microbiota and HPV Infection and Cervical Lesions. Journal of Molecular Diagnosis and Therapy, 16(03), 586-590.

[8] Wang Haixia, Liu Yanmin, Cheng Chao, Ma Yueying, Ma Xiaohong & Li Xiaojun. (2020). Common Lactobacillus in the vagina and related research progress. Chinese Journal of Mi-croecology, 32(05), 601-605.

[9] Wu, Aihua. (2024). Analysis of the evaluation value of routine tests for leukorrhea and bacterial vaginosis on the vaginal mi-croecology of women. Chinese Modern Drug Applica-tion, 18(18), 64-68.

[10] Xu Yinghui & Deng Yanjie. (2024). Analysis of HPV infection status and changes in vaginal flora in patients with cervical lesions. Chinese Journal of Microecology, 36(10), 1231-1236.

[11] Wu Zonghui, Ye Haiqiong & Yuan Yuan. (2017). Analysis of factors influencing vaginal flora disorder in patients with vaginitis and research on countermeasures. Chinese Journal of Maternal and Child Health, 32(01), 118-121.

[12] Zhang Wei. (2020). Clinical observation of the therapeutic effect of Lactobacillus live bac-teria capsules on the recovery of vaginal microecological environment in patients with vaginitis. Chinese Modern Drug Application, 14(04), 156-157.

[13] Zhi Xiuxia, Milan, Liu Chaohui & Zhang Dai. (2020). Analysis of the status and influencing factors of vaginal microecological envi-ronment in 701 healthy women. Clinical Medicine Literature Elec-tronic Journal, 7(10), 15-17.

[14] Ganguly N, Parihar SP. Human papillomavirus E6 and E7 on-coproteins as risk factors for tumorigenesis. J Biosci. 2009;34(1):113-23.

[15] Ganguly N. Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value. Cell Oncol (Dordr). 2012;35(2):67-76.

[16] Alemi M, Mohabatkar H, Behbahani M. In silico comparison of low- and high-risk human papillomavirus proteins. Appl Biochem Biotechnol. 2014;172(1):188-95.

[17] De Martino S, Capasso B, Cis L, et al. Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells. Crit Rev On-col Hematol. 212:104771.

[18] Mohammed MM, Al-Khafaji ZAI, Al-Hilli NM. An exploration of the natural and acquired immunological mechanisms to high-risk human papillomavirus infection and unmasking immune escape in cervical cancer: A concise synopsis. Tzu Chi Med J. 2025 Jan-Mar;37(1):28-41

[19] Mazinani S, Aghazadeh M, Poortahmasebi V, Arafi V, Hasani A. Cervical cancer pathology and vaginal and gut microbiota: con-ception of the association. Lett Appl Microbiol. 2025;78(7). doi:10.1093/lambio/ovaf088

[20] Ye J, Qi X. Vaginal microecology and its role in human papillo-mavirus infection and hu-man papillomavirus associated cervical lesions. APMIS. 2024;132(12):928-947.

[21] Avsaroglu E, Kaleli B, Kilic D, Kaleli I, Guler T. A Decrease in Lactobacilli in the Vaginal Mi-crobiota Is Independently Associated With HPV Persistence in Women With High-Risk HPV Infection. Cureus. 2023;15(12):e50907. Published 2023 Dec.

[22] Dou P, Fang F, Qin R, et al. Vaginal flora in HPV infection: a cross sectional analysis. J Obstet Gynaecol. 2024;44(1):2361847.

[23] Chen Y, Qiu X, Wang W, et al. Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort. BMC Infect Dis. 2020;20(1):629. Published 2020 Aug 26.

[24] Doorbar J. Host control of human papillomavirus infection and disease. Best Pract Res Clin Obstet Gynaecol. 47:27-41.

[25] Nicolò S, Antonelli A, Tanturli M, et al. Bacterial Species from Vaginal Microbiota Differ-ently Affect the Production of the E6 and E7 Oncoproteins and of p53 and p-Rb Oncosup-pressors in HPV16-Infected Cells. Int J Mol Sci. 2023;24(8). Published 2023 Apr 12.

[26] Huang R, Liu Z, Sun T, Zhu L. Cervicovaginal microbiome, high-risk HPV infection and cer-vical cancer: Mechanisms and therapeutic potential. Microbiol Res. 287:127857.

[27] Kim S, Cawiding OR, de Los Reyes V AA, Choi S. Qualitative assessment of sex-stratified human papillomavirus transmission dynamics in South Korea. BMC Public Health. 2025;25(1):2686. Published 2025 Aug 6.

[28] Stanley M. Prevention strategies against the human papilloma-virus: the effectiveness of vaccination. Gynecol Oncol. 2007;107(2 Suppl 1):S19-23.

[29] Pahud BA, Ault KA. The Expanded Impact of Human Papillo-mavirus Vaccine. Infect Dis Clin North Am. 2015;29(4):715-24.

[30] Tachedjian, G., Aldunate, M., Bradshaw, C. S., & Cone, R. A. (2017). The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in microbiology, 168(9-10), 782–792.

[31] Yockey, L. J., Hussain, F. A., Bergerat, A., Reissis, A., Worrall, D., Xu, J., Gomez, I., Bloom, S. M., Mafunda, N. A., Kelly, J., Kwon, D. S., & Mitchell, C. M. (2022). Screening and characteriza-tion of vaginal fluid donations for vaginal microbiota transplanta-tion. Scientific reports, 12(1), 17948.

[32] Joseph, R. J., Ser, H. L., Kuai, Y. H., Tan, L. T., Arasoo, V. J. T., Letchumanan, V., Wang, L., Pus-parajah, P., Goh, B. H., Ab Mutalib, N. S., Chan, K. G., & Lee, L. H. (2021). Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vagi-nosis?. Antibiotics (Basel, Switzer-land), 10(6), 719.

[33] Ye, J., & Qi, X. (2024). Vaginal microecology and its role in human papillomavirus infection and human papillomavirus associated cervical lesions. APMIS : acta pathologica, microbi-ologica, et immunologica Scandinavica, 132(12), 928–947.

[34] Wei, Z. T., Chen, H. L., Wang, C. F., Yang, G. L., Han, S. M., & Zhang, S. L. (2021). Depiction of Vaginal Microbiota in Women With High-Risk Human Papillomavirus Infection. Frontiers in public health, 8, 587298.

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Published

2025-08-25

How to Cite

A review of the correlation between human papillomavirus (HPV) infection and dysbiosis of the female reproductive tract. (2025). Health, Medicine and Therapeutics, 1(1), 54-61. https://doi.org/10.63313/hmt.9007