Advances in the Synthesis and Applications of α-Amino Phosphates
DOI:
https://doi.org/10.63313/AERpc.2006Keywords:
α-Amino phosphates, pharmaceutical, remarkable biologicalAbstract
α-Amino phosphates (α-APs) are an important class of organophosphorus compounds that contain both amino and phosphate functional groups at the same carbon center. These compounds exhibit remarkable biological, pharmaceutical, and catalytic properties, making them valuable intermediates in drug synthesis, peptide chemistry, and material sciences. This review provides an overview of the recent progress in the synthesis, reactivity, and applications of α-APs, emphasizing novel catalytic methodologies, green synthetic approaches, and their emerging roles in various scientific fields.
References
[1] Duchateau A.L.L., Crombach M.G. Determination of α-aminonitriles, α-amino acid amides and α-amino acids by means of HPLC, post-column reaction and fluorescence detection [J]. Chromatographia, 1987, 24(1): 339-43.
[2] Ciapetti P., Falorni M., Taddei M. CrCl2 Mediated addition of allylic halides or phosphates to N-protected α-amino aldehydes. Stereocontrolled synthesis of a new core for C2 symmet-ric HIV-protease inhibitors [J]. Tetrahedron, 1996, 52(21): 7379-90.
[3] Lee M.-Y., Chang J.-K., Wu C.-C., et al. Ionic Liquid-Modified Copper Phosphate Electrodes for the Detection of α-Amino Acids in a Weakly Alkaline Solution [J]. Journal of The Elec-trochemical Society, 2016, 163(14): B768.
[4] Wang G., Zeng Y.-H., Jiang Q.-Y., et al. Iron(iii)-catalyzed mono-, di- and tricyanomethyla-tion of primary amines with diazoacetonitrile: construction of α-amino acetonitriles and asymmetric α-amino succinonitriles [J]. Organic Chemistry Frontiers, 2025, 12(6): 1992-2003.
[5] Zhang Q., Wang J., Lan F., et al. Synthesis and DNA interaction of aloe-emodin α-amino phosphate derivatives [J]. Journal of Molecular Structure, 2023, 1279: 134950.
[6] Kumar H., Behal I. Volumetric and ultrasonic properties of α-amino acids (glycine, l-alanine and l-valine) in aqueous diammonium hydrogen phosphate at different temper-atures and concentrations [J]. Journal of Molecular Liquids, 2017, 241: 751-63.
[7] Lee M.-Y., Ding S.-J., Wu C.-C., et al. Fabrication of nanostructured copper phosphate elec-trodes for the detection of α-amino acids [J]. Sensors and Actuators B: Chemical, 2015, 206: 584-91.
[8] Zahouily M., Elmakssoudi A., Mezdar A., et al. Natural phosphate and potassium fluoride doped natural phosphate catalysed simple one-pot synthesis of α-amino phosphonates under solvent-free conditions at room temperature [J]. Catalysis Communications, 2007, 8(3): 225-30.
[9] Kong X., Peng Z. Low-dimensional materials for alkaline oxygen evolution electrocatalysis [Z]. Materials Today Chemistry. Elsevier Ltd. 2019: 119-32.10.1016/j.mtchem.2018.10.011
[10] Lai W., Qiao Y., Zhang J., et al. Design strategies for markedly enhancing energy efficiency in the electrocatalytic CO2 reduction reaction [J]. Energy Environ Sci, 2022, 15(9).
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