Engineering Biomimetic and Multifunctional Artificial Periosteum via Electrospinning for Bone Regeneration
DOI:
https://doi.org/10.63313/AERpc.2020Keywords:
Electrospinning, Nanofibers, Artificial Periosteum, Bone RegenerationAbstract
This review delves into the advancements and strategies in electrospinning for the development of artificial periosteum in bone regeneration. Electrospun nanofibers offer advantages such as high surface area, porosity, and multifunctionality, making them suitable for mimicking the natural periosteum. The focus of this review lies in the recent progress in crafting electrospun artificial periosteum. It elucidates the histological structure and function of the periosteum, emphasizing its pivotal role in bone repair. Various materials, encompassing natural and synthetic polymers, are scrutinized for the design of effective artificial periosteum. Furthermore, it explores the utilization of diverse electrospinning process and other technologies such as phase separation and sol-gel method, which can be amalgamated with electrospinning for artificial periosteum development. Additionally, it delves into synergistic regulation of multidimensional osteogenic cues and the crucial osteogenic-angiogenic coupling effect for bone healing. In conclusion, limitations of current techniques and strategies are outlined, alongside future prospects for the application of advanced electrospinning technologies in the preparation of artificial periosteum.
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